Accession Number : AD0784927

Title :   The Antiviral Effect of Some Derivatives of Tilorone HCl on TBE in White Mice,

Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD

Personal Author(s) : Hofmann,Hanns ; Kunz,Christian ; Dippe,H.

Report Date : 18 SEP 1974

Pagination or Media Count : 13

Abstract : Four derivatives of tilorone HCl were tested against tickborne encephalitis (TBE) in mice and compared with tilorone HCl. All substances induced interferon and thus protected mice against infection. The drugs were active not only after oral but also after subcutaneous and intraperitoneal application. Rather an antagonistic effect was observed when the compounds were used combined. However treatment of mice with tilorone HCl or a derivative in combination with Poly I:C enhanced survival of mice. (Author)

Descriptors :   *Encephalitis, *Virus diseases, *Antiviral agents, Infectious diseases, Disease vectors, Ticks, Drugs, Mice, Experimental data, Translations, West Germany

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE