Accession Number : AD0784928

Title :   Experience with Kanamycin Electroaerosols in Pediatric Practice,

Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD

Personal Author(s) : Prokhorova,I. I. ; Lutsik,V. S. ; Khoperia,A. I. ; Marisenko,G. P. ; Eidelshtein,S. I.

Report Date : 18 SEP 1974

Pagination or Media Count : 9

Abstract : The children treated in tests tolerated the inhalation of kanamycin electroaerosol quite well; in no case was any irritation of the mucous membranes of the respiratory tract, or impairment of hearing or of kidney function, observed. Absorption of kanamycin during inhalation of the electroaerosol was insignificant, and did not give rise to any threat of general toxic action. Not more than 3% of the inhaled dose was excreted in the urine. High concentrations of kanamycin were observed in the sputum after 24 hours of treatment. A significant quantity of the antibiotic was also found in the lavage fluid following puncture of the maxillary sinuses. Inhalation of kanamycin electroaerosol is an effective method of treating flare-ups of chronic pneumonia in children. Apart from favorable clinical signs, this is confirmed also by studies of blood gases and certain indices of the acid-base balance.

Descriptors :   *Antibiotics, *Respiratory diseases, *Aerosols, Inhalation, Chemotherapeutic agents, Drugs, Children, USSR, Translations

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE