Accession Number : AD0785210

Title :   Experimental Study of the Effect of the Dose of a Chemical Substance on the Incidence and Intensity of Contact Allergy,

Corporate Author : FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s) : Alekseeva,O. G. ; Barlogova,S. G. ; Dueva,L. A. ; Zagidullin,Sh. Z. ; Raben,A. S.

Report Date : 21 AUG 1974

Pagination or Media Count : 11

Abstract : A direct relationship exists between the dose of a chemical allergen and the intensity of contact allergy. In a large number of chemical allergens, the threshold of allergizing action is below the threshold of toxic action during absorption through the skin. On this basis when setting permissible standards it is not necessary to consider the specific effect. Certain weak allergens can be active sensitizers even in toxic doses.

Descriptors :   *Allergic diseases, *Dermatitis, Antigens, Chemical agents, Dosage, Skin(Anatomy), Toxicity, Thresholds(Physiology), Industrial medicine, Immunology, USSR, Translations

Subject Categories : Medicine and Medical Research
      Environmental Health and Safety

Distribution Statement : APPROVED FOR PUBLIC RELEASE