Accession Number : AD0785524

Title :   Localization of the Antinociceptive Action of Morphine in Primate Brain.

Descriptive Note : Technical rept. Dec 73-Dec 74,

Corporate Author : EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

Personal Author(s) : Pert,A. ; Yaksh,T.

Report Date : AUG 1974

Pagination or Media Count : 11

Abstract : Microinjections of morphine sulfate (20 to 40 micrograms were made into various subcortical regions of the rhesus monkey brain. The effects of these injections were evaluated on the nociceptive threshold, as defined by the shock titration technique. The results of this preliminary investigation indicate that the region of maximal antinociceptive sensitivity to morphine in the primate is the periventricular-periaqueductal gray matter. It is tentatively suggested that morphine lowers the affective tone or the aversive component of pain by its action on the midbrain central gray and periventricular areas - both important projection and integration areas of the extralemniscal somatosensory system. (Author)

Descriptors :   *Morphine, *Analgesia, Dosage, Pharmacology, Brain, Analgesia, Primates, Experimental data

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE