Accession Number : AD0785761

Title :   Genetic Studies on Scrub Typhus and Spotted Fever Rickettsiae.

Descriptive Note : Final rept. 1 Jul 73-30 Jun 74,

Corporate Author : MARYLAND UNIV BALTIMORE DEPT OF MICROBIOLOGY

Personal Author(s) : Osterman,Joseph V. , Jr

Report Date : 01 JUL 1974

Pagination or Media Count : 15

Abstract : The research program consists of two interrelated areas of work, both aimed at understanding the genetic basis of variation in scrub typhus organisms. It was felt that a combined program, studying both nucleic acid synthesis and genetics, was the most logical approach to this problem. Once the mechanism of variation was revealed, it might be possible to influence changes in the rickettsiae by chemical mutagenesis and develop strains particularly suitable for vaccine development which contain multiple major surface antigens. (Modified author abstract)

Descriptors :   *Genetics, *Rickettsia tsutsugamushi, Typhus, Nucleic acids, Biosynthesis, Antigens

Subject Categories : Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE