Accession Number : AD0786519

Title :   Preliminary Assessment of Relative Toxicity of Several Pesticide Compounds in Behavioral Screening Tests.

Descriptive Note : Rept. for Jun 73-Jan 74,

Corporate Author : ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD

Personal Author(s) : Smith,William M. , Jr

Report Date : JAN 1974

Pagination or Media Count : 10

Abstract : Four pesticide compounds were tested for detrimental effects on the behavior of rats trained to avoid electric shock in a modified shuttlebox procedure. ED50 values ('effective dose' for producing nonresponse in 50 percent of the subjects) were determined for Mobam, Abate, Malathion and ENT-27699. The following ED50 values were determined in this test situation: Malathion, tested at 30 minutes post-injection, 550 mg/kg; Abate, tested 1 hour post-injection, 500 mg/kg; ENT-27699, tested 1 hour post-injection, 1000 mg/kg; Mobam, tested 15 minutes post-injection, 10 mg/kg. Control subjects injected with cornoil or with isotonic saline showed no dose-response effect in this test situation, i.e., they successfully avoided the electric shock by responding during the preshock tone. (Author)

Descriptors :   *Pesticides, *Behavior, Toxicology, Rats, Laboratory animals, Experimental data, Psychophysiology, Dosage, Chemical compounds, Response(Biology), Avoidance, Performance(Human), Bioassay, Conditioned response

Subject Categories : Psychology
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE