Accession Number : AD0787536

Title :   Intrarenal Regulating Mechanisms for Renal Hemodynamics during Shock.

Descriptive Note : Final technical rept.,

Corporate Author : MUNICH UNIV (WEST GERMANY) PHYSIOLOGISCHES INSTITUT

Personal Author(s) : Thurau,Klaus

Report Date : JUL 1974

Pagination or Media Count : 19

Abstract : Renin activity of single, microdissected juxtaglomerular apparatuses (JGAs) and glomerular filtration rate were measured in the rat kidney before and during acute renal failure induced by total renal ischaemia. During renal failure JGA renin activity was increased and glomerular filtration rate (GFR) reduced. The increase in JGA renin activity was reduced or abolished by the use of an angiotensin II analogue and a converting inhibitor. GFR was slightly improved under these conditions. The combination of angiotensin analogue with a-methyldopa was more effective in restoring GFR. Using immuno assay methods the presence of angiotensin I and II in the renal tissue of rats was demonstrated. Methodological difficulties still exist in quantifying converting enzyme activities in the renal tissue. Using micropuncture techniques the operation of the feedback control of single nephron filtration rate was demonstrated in the post-ischaemic kidney during acute renal insufficiency. (Author)

Descriptors :   *Kidney function tests, *Shock(Pathology), *Blood circulation, Rats, Laboratory animals, Kidneys, West Germany, Physiology, Pathology

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE