Accession Number : AD0800188

Title :   EFFECTS OF BETA-RADIATION ON THE INTERMEDIARY METABOLISM OF MAMMALIAN SKIN.

Descriptive Note : Final progress rept.,

Corporate Author : MICHIGAN UNIV ANN ARBOR

Personal Author(s) : Bernstein, I. A.

Report Date : 30 APR 1966

Pagination or Media Count : 7

Abstract : This project was initiated with the specific objective of determining whether radiation interfers with the availability of chemical energy since Swann had proposed that the filling of an energy reservoir was necessary before mitosis occurred and the biosynthesis of DNA and RNA were energy-requiring processes. The following three possible mechanisms for such a radiation effect were considered: (1) the high-energy compounds themselves (e.g. adenosine triphosphate (ATP), uridine triphosphate (UTP), acyl thioesters, etc.) might be destroyed; (2) there might be a decrease in the rate of synthesis of such energy-rich compounds and (3) there might be an alteration in the pathways of carbon metabolism which per se, would result in the conservation of less energy in usable chemical form.

Descriptors :   *RADIATION EFFECTS), (*METABOLISM, (*BETA PARTICLES, METABOLISM), MAMMALS, SKIN(ANATOMY), LABORATORY ANIMALS, RADIOACTIVE ISOTOPES, MITOSIS, TRACER STUDIES, PHOSPHATES, DEOXYRIBONUCLEIC ACIDS, RIBONUCLEIC ACIDS, LETHAL DOSAGE, RADIOGRAPHY, CARBON, TISSUES(BIOLOGY), BIOSYNTHESIS, IN VIVO ANALYSIS, IN VITRO ANALYSIS.

Subject Categories : Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE