Accession Number : AD0804282

Title :   ON THE COOPERATIVITY OF BIOLOGICAL MEMBRANES.

Descriptive Note : Technical rept.,

Corporate Author : CALIFORNIA UNIV BERKELEY DEPT OF PHYSICS

Personal Author(s) : Changeux, Jean-Pierre ; Thiery, Jean ; Tung, Yvonne ; Kittel, C.

Report Date : NOV 1966

Pagination or Media Count : 17

Abstract : We extend the Monod-Wyman-Changeux of allosteric transitions in enzyme-substrate reactions to a membrane composed of identical units (protomers). It is supposed that each protomer can exist in two states. The interaction between protomers is treated in the molecular field approximation. It appears possible to have a first-order phase transition when the chemical potential of the substrate is varied, holding the temperature constant. The wide range of possible biological implications is discussed. (Author)

Descriptors :   (*MEMBRANES(BIOLOGY), RESPONSE(BIOLOGY)), IN VIVO ANALYSIS, IN VITRO ANALYSIS, THEORY, LIPOPROTEINS, ENZYMES, APPROXIMATION(MATHEMATICS), PREDICTIONS, MATHEMATICAL MODELS, PHARMACOLOGY, DRUGS, PERMEABILITY.

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE