Accession Number : AD0806401

Title :   EFFECTS OF ATROPINE AND PILOCARPINE ON HUMAN THERMOREGULATION,

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : Palmes, Edward D. ; Schachner, H. G. ; Albert, Roy E. ; Hart, J. J.

Report Date : 14 APR 1948

Pagination or Media Count : 6

Abstract : An attempt was made to determine the manner and extent of compensation to the thermal stresses imposed by the injection of atropine and pilocarpine. Complete thermal balance studies were made on subjects before and after subcutaneous injection of these drugs at two different ambient temperatures. Changes in evaporative rate produced by these drugs are thermally compensated by alterations in convection and radiation and, under some conditions, in peripheral blood flow and metabolism. The compensatory mechanisms are not sufficiently prompt nor large enough to maintain thermal balance immediately after the injection. They persist, however, much longer than does the altered evaporative rate. The 'atropine flush' is a reaction secondary to a reduction in evaporative rate. (Author)

Descriptors :   (*BODY TEMPERATURE, DRUGS), ALKALOIDS, ATROPINE, EQUILIBRIUM(PHYSIOLOGY), STRESS(PHYSIOLOGY), THERMAL STRESSES, RESPONSE(BIOLOGY), EVAPORATION, METABOLISM, BLOOD CIRCULATION, DOSAGE, INJECTIONS(MEDICINE).

Subject Categories : Anatomy and Physiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE