Accession Number : AD0806405

Title :   REGULATORY EFFECT OF THE BLOOD GLUCOSE LEVEL ON THE SECRETION OF THE ADRENAL CORTEX,

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : Steeples, G. L., Jr. ; Jensen, H. F.

Report Date : 01 JAN 1949

Pagination or Media Count : 6

Abstract : In the course of studies designed to determine the effects of hypothermia on the contol of endocrine secretions it became necessary to know the effects of changes in blood glucose level on the secretory activity of the adrenal cortex. Alterations in the cholesterol content of the adrenals were used as indices of the activity of the gland. Hyperglycemia induced by oral administration of glucose produced an increase in the adrenal cholesterol indicating an inhibition of the adrenal cortex. After thirty to sixty minutes the adrenal cholesterol returned to normal values. Hypoglycemia induced by insulin injection produced a decrease in the adrenal cholesterol indicating a stimulation of the adrenal cortex. The role of the blood glucose level in the regulation of the secretion of insulin, on the one hand, and of epinephrine, on the other, is a possibility.

Descriptors :   (*ADRENAL CORTEX, SECRETION), BLOOD CHEMISTRY, GLUCOSE, PHYSIOLOGY, CHOLESTEROL, HYPERGLYCEMIA, HYPOGLYCEMIA, EQUILIBRIUM(PHYSIOLOGY), INHIBITION, INSULIN, HYPOTHERMIA.

Subject Categories : Anatomy and Physiology
      Stress Physiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE