Accession Number : AD0806410

Title :   THE PRODUCTION OF CHRONIC SYSTEMIC HYPERTENSION IN THE RAT WITH A SMALL ADJUSTABLE RENAL ARTERY CLAMP,

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : Munnell, Edward R. ; Gregg, Donald E.

Report Date : 02 SEP 1949

Pagination or Media Count : 11

Abstract : An adequate method for the production of a persistent elevation of systemic blood pressure in the rat was desired. Several existing methods were tested. A small adjustable silver clamp, modeled after the larger Goldblatt clamp was developed for application to and constriction of the renal arteries. Using published methods for inducing hypertension, only 15 per cent of the rats developed a persistent elevation of blood pressure. Bilateral application and adjustment of the renal artery clamp at one operation has caused in 10 of 11 rats a persistent elevation of blood pressure. The augmented blood pressure developed in 4-40 days and ranged from 160-220mm. Hg. In rats operated upon with application and immediate removal of clamps (controls), pressures ranged from 100-140 mm. Hg. Eight of the 11 rats are alive and well 3-5 months after operation. These studies are being extended. (Author)

Descriptors :   (*HYPERTENSION, TEST METHODS), CARDIOVASCULAR SYSTEM, BLOOD PRESSURE, RATS, KIDNEYS, ARTERIES, CLAMPS.

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE