Accession Number : AD0806417

Title :   BLOOD AMINO ACID LEVEL AND ADRENAL CHOLESTEROL CONTENT DURING TOURNIQUET SHOCK IN THE RAT WITH AND WITHOUT SALINE ADMINISTRATION,

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : Gray, John L. ; Botkin, Albert L. ; Moulden, Elizabeth J. ; Jensen, Hans F.

Report Date : 10 AUG 1950

Pagination or Media Count : 10

Abstract : In the course of studies designed to investigate the 'sparing' effect of saline administration in lowering mortality of rats in 'tourniquet shock' it became of interest to know the influence of this therapy on the blood amino acid level and the adrenal cholesterol content. A shock-like state was produced in rats by applying rubber band tourniquets to the limbs for a certain length of time and then releasing them. A progressive increase in blood amino acid and urea nitrogen occurred after the release of the tourniquets. Application of the rubber bands per se had no effect on these blood constituents but was found to cause a definite stimulation of the adrenal cortex as indicated by a lowering of the adrenal cholesterol content. Release of the tourniquets produced a further decline in the adrenal cholesterol content. The 'sparing' effect of 0.9 percent NaCl administration to rats during 'tourniquet shock' was found to be associated with a decrease in the elevation of blood amino acid concentration and in the fall in the adrenal cholesterol content when compared with untreated animals.

Descriptors :   (*SHOCK(PATHOLOGY), BLOOD ANALYSIS), BLOOD PLASMA SUBSTITUTES, SODIUM CHLORIDE, SOLUTIONS(MIXTURES), PARENTERAL INFUSIONS, THERAPY, AMINO ACIDS, ADRENAL GLANDS, CHOLESTEROL, SURVIVAL(PERSONNEL), RATS.

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE