Accession Number : AD0806419

Title :   THE EXCRETION AND DISTRIBUTION OF LITHIUM IN THE DOG.

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : Clarke, R. W. ; Talso, P. J. ; Moulden, Elizabeth J. ; Graham, Irven C.

Report Date : 20 SEP 1950

Pagination or Media Count : 16

Abstract : The experiments here reported were carried out to investigate the renal excretion of lithium administered to experimental animals. The distribution of the salt in the body, its excretion by extrarenal routes, and some observations on its toxicity were included, the whole study being planned to obtain information bearing on the use of lithium salts by man. Injected lithium (as chloride) is rapidly excreted, approximately at the same rate as potassium. Small quantities are excreted by way of the gastrointestinal tract. It appears to be uniformly distributed in the body water when equilibrium is reached. It is excreted by the kidneys by glomerular filtration followed by tubular reabsorption of 57 to 99 percent of the filtered quantity, at serum lithium levels up to 17 mEq/L. The renal tubules show little evidence that they can distinguish between lithium and potassium. In these experiments no interference by lithium with the excretion of sodium was noted.

Descriptors :   (*KIDNEYS, LITHIUM COMPOUNDS), URINE, EXCRETION, METABOLISM, BODY FLUIDS, DISTRIBUTION, SODIUM, POTASSIUM, CHLORIDES, INGESTION(PHYSIOLOGY), PARENTERAL INFUSIONS, BIOCHEMISTRY, BLOOD SERUM, CONCENTRATION(CHEMISTRY).

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE