Accession Number : AD0806439

Title :   THE LOCAL EFFECT OF SEROTONIN UPON RENAL VASCULAR RESISTANCE AND URINE FLOW RATE,

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : Emanuel, D. A. ; Scott, J. ; Collins, R. ; Haddy, F. J.

Report Date : 06 AUG 1958

Pagination or Media Count : 15

Abstract : An attempt was made to study the renal vascular resistance and urine flow changes upon infusion of serotonin into the renal artery of the dogy. Serotonin was infused into the renal artery of 37 dogs at 10 and 100 micro gm/min. The kidneys were studied with intact renal nerves, after denervation, and following denervation plus infusion of phentolamine. Blood flow rate was controlled and uncontrolled. Renal vascular resistance increased, on the average, 23% above the control level in the nerve intact and denervated kidneys and about half this amount in the denervated kidneys infused with phentolamine. Significant changes in urine flow rate were not observed. Gross and microscopic examination of the kidneys revealed no specific pathological lesions. The local effect of serotonin when infused into the renal artery of the dog is a moderate active increase in renal vascular resistance through some mechanism unrelated to extrinsic nerves and circulating or locally released catecholamines. Regular changes in urine flow rate were not observed and the antidiuresis reported by others following systemic administration must result from indirect action on the kidney. (Author)

Descriptors :   *KIDNEYS), (*SEROTONIN, URINARY SYSTEM, URINE, EXCRETION, TOLERANCES(PHYSIOLOGY), RESPONSE(BIOLOGY), BLOOD CIRCULATION, PATHOLOGY, MICROSCOPY, MEDICAL EXAMINATION, PARENTERAL INFUSIONS.

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE