Accession Number : AD0808732

Title :   A CLINICOPATHOLOGIC STUDY OF THE EFFECTS OF RIOT CONTROL AGENTS ON MONKEYS. IV. O-CHLOROBENZYLIDENE MALONONITRILE (CS) GRENADE.

Descriptive Note : Technical rept. Nov 65-Jun 66,

Corporate Author : EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

Personal Author(s) : Striker, G. E. ; Streett, C. S. ; Ford, D. F. ; Herman, L. H. ; Helland, D. R.

Report Date : JAN 1967

Pagination or Media Count : 39

Abstract : This is a study of the order, severity, and resolution of pathologic changes in Macaca mulatta monkeys exposed to CS, a riot control agent. When monkeys were exposed to CS (Ct's of 2700, 8500, 28,500, or 80,000 mg min/cu m), the following observations were made: 1. The most prominent lesions seen after the two lower doses were mild pulmonary congestion, bronchorrhea, emphysema, and atelectasis. These lesions cleared by 72 hr but recurred at 1 wk and 30 days. 2. Oral and nasal discharges and dyspnea appeared early after a Ct of 28,500. They were most severe between 12 and 24 hr and were resolved by 72 hr. Pneumonia, emphysema, and atelectasis were present 1 wk and 30 days after exposure. 3. Significant lesions were seen radiographically only in those monkeys exposed to a Ct of 80,000. These lesions paralleled those seen on necropsy. At this Ct, edema appeared by 12 hr, peaked between 24 and 48 hr, and cleared by 1 wk. Emphysema and bronchiolitis were present 1 wk and 30 days after exposure. (Author)

Descriptors :   (*TEAR GAS, EFFECTIVENESS), MONKEYS, PATHOLOGY, GRENADES, WOUNDS AND INJURIES, LUNG, AEROSOLS, HISTOLOGY.

Subject Categories : Medicine and Medical Research
      Chemical, Biological and Radiological Warfare

Distribution Statement : APPROVED FOR PUBLIC RELEASE