Accession Number : AD0818421

Title :   PHARMACOLOGICAL AND BIOCHEMICAL CHANGES IN ANIMALS MADE AGGRESSIVE BY ISOLATION.

Descriptive Note : Final technical rept. May 66-Apr 67,

Corporate Author : ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI MILAN (ITALY)

Personal Author(s) : Dolfini, E. ; Garattini, Silvio ; Giacalone, E. ; Valzelli, L.

Report Date : MAY 1967

Pagination or Media Count : 30

Abstract : A large number of psychoactive drugs were tested on the aggressiveness induced by isolation; till now only ampizine, chlordiazepoxide and its derivatives have shown a certain degree of effectiveness. In aggressive animals the level of 5-hydroxyindolacetic acid was found to be consistently lower than in the controls while the turnover rates of serotonin and noradrenalin were found to increase. However, brain serotonin turnover could not be used to predict whether a strain of mice would or would not develop aggressiveness upon isolation. In addition in female mice, which consistently do not become aggressive after isolation, serotonin turnover rates were found to be higher than the turnover rates of the males of the same strain which do develop isolation aggressiveness. (Author)

Descriptors :   (*PSYCHOCHEMICAL AGENTS, EFFECTIVENESS), CONFINEMENT(PSYCHOLOGY), BIOCHEMISTRY, PSYCHOTROPIC AGENTS, PHARMACOLOGY, DRUGS, TRANQUILIZERS, BRAIN, SEROTONIN, MICE, RATS, TABLES(DATA), ITALY, FEAR, STRESS(PSYCHOLOGY), BEHAVIOR, CENTRAL NERVOUS SYSTEM.

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE