Accession Number : AD0819208

Title :   SYNTHESIS OF AMINO AND HYDRAZINO DERIVATIVES OF ALICYCLIC AND HETEROCYCLIC SYSTEMS WITH POTENTIAL PHARMACOLOGICAL ACTIVITY ON C.N.S.

Descriptive Note : Final technical rept. Jun 66-May 67,

Corporate Author : GENOA UNIV (ITALY) ISTITUTO DI CHIMICA FARMACEUTICA E TOSSICOLOGICA

Personal Author(s) : Gandini, Andrea ; Minardi, Giovanna ; Schenone, Pietro ; Bignardi, Gaetano

Report Date : JUN 1967

Pagination or Media Count : 20

Abstract : In fulfillment of the research project directed toward the preparation of compounds with potential activity on C.N.S., a group of 10 pyrazoles (probable formula I) was prepared, from 6-methyl- and 6-chloro-3-hydroxymethylene-4- chromanones by reaction with various dialkylaminoalkylhydrazines. A number of hydrazino derivatives of alicyclic compounds (formula IV) were obtained from 2-arylcyclohexanones acetylhydrazones by catalitic reduction to 1-acetyl-2(2'-arylcyclohexyl)hydrazines. Another group of hydrazino derivatives (formula VII) was obtained by reaction between 1-aryloxy-2,3-epoxypropanes and hydrazine. Finally, in order to obtain compounds with probable anti MAO activity, some compounds of Pargyline type (formula IX) were synthesized, starting from a terpenoid amine, camphidine. (Author)

Descriptors :   (*AMINES, SYNTHESIS(CHEMISTRY)), (*HYDRAZINE DERIVATIVES, SYNTHESIS(CHEMISTRY)), (*NITROGEN HETEROCYCLIC COMPOUNDS, SYNTHESIS(CHEMISTRY)), POLYCYCLIC COMPOUNDS, CHEMICAL PROPERTIES, MOLECULAR STRUCTURE.

Subject Categories : Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE