Accession Number : AD0825760

Title :   THE ALTERATION OF VISUAL PERCEPTUAL MECHANISMS BY CHEMICAL AGENTS.

Descriptive Note : Final rept.,

Corporate Author : STANFORD UNIV CA SCHOOL OF MEDICINE

Personal Author(s) : Killam, Keith F., Jr

Report Date : JUL 1967

Pagination or Media Count : 35

Abstract : Cats with electrodes chronically implanted in cortical, subcortical and rhinencephalic structures of the brain were conditioned to press one of three panels for positive reinforcement. The visual conditioned stimulus (CS) was presented at 10 cps in three paradigms: (1) selection of the single lighted panel (light-dark discrimination); (2) discrimination between similar patterns presented at differing intensities (total luminous flux discrimination); and (3) discrimination between two differing geometric patterns of similar intensity. The CS figures were pulsed to allow frequency labeling of brain bioelectric activity. This activity was collected during habituation to the conditioning stimulus, during training and during stabilized performance of the behavior. Atropine sulfate (0.25-1 mg/kg), LSD-25 (25-100 mcg/kg), chlorpromazine (1-5 mg/kg) and trifluoperazine (0.5-2 mg/kg) altered performance and associated EEG responses to the CS differently depending upon the paradigm. The bioelectric data were examined for changes associated with the behavioral state with the aid of a LINC computer using the following treatments: averaging, autocorrelation, cross correlation, autospectra, period analysis, and a variety of pattern recognition schemes. The data indicate that there are recognizable changes associated with the level of training and the correctness of performance, as well with pharmacological alteration of behavior. (Author)

Descriptors :   *VISUAL PERCEPTION), (*PSYCHOTROPIC AGENTS, CONDITIONED RESPONSE, BEHAVIOR, HABITUATION LEARNING, ATROPINE, LYSERGIC ACIDS, CHLORPROMAZINE, ELECTROENCEPHALOGRAPHY, TRAINING, PATTERN RECOGNITION, STATISTICAL ANALYSIS.

Subject Categories : Psychology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE