Accession Number : AD0833591

Title :   THE NONSPECIFICITY OF THE INDIRECT HEMAGGLUTINATION REACTION IN DETECTION OF BOTULINE TOXINS IN FOODSTUFFS,

Corporate Author : ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s) : Bulatova, T. I.

Report Date : 1968

Pagination or Media Count : 14

Abstract : To detect botulin in foodstuffs the indirect hemagglutination reaction was used. This reaction proved to be a rather rapid and sensitive method of laboratory diagnosis. It cannot, however, replace completely the biological test. In experiments with weak toxins this method appeared much more sensitive, as compared to the biological test, but in experiments with strong toxins it was inferior to the latter. With the aid of indirect hemagglutination reaction it was impossible to differentiate botulins of the A and B types. Besides, the same positive response was obtained in experiments both with botulins and toxoids of the A and B types, and with nontoxic filtrates of Cl. sporogenes, this being due to the presence in them of common somatic antigens. Thus, indirect hemagglutination reaction cannot be used for detecting botulin in foodstuffs. (Author)

Descriptors :   (*TOXINS AND ANTITOXINS, DETECTION), FOOD POISONING, CLOSTRIDIUM BOTULINUM, FOOD, SERODIAGNOSIS, IMMUNE SERUMS, ERYTHROCYTES, ANTIGEN ANTIBODY REACTIONS, USSR.

Subject Categories : Toxicology
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE