Accession Number : AD0837124

Title :   MECHANISMS OF ACTION OF ANTIMALARIAL DRUGS,

Corporate Author : WALTER REED ARMY INST OF RESEARCH WASHINGTON DC

Personal Author(s) : Hahn, Fred E.

Report Date : 1968

Pagination or Media Count : 15

Abstract : The studies elucidate the mechanism of action of chloroquine at the molecular level. The results of the study are relevant to the practical problem of drug resistance in malaria in that they lead to the following conclusions: (1) It is doubtful that further development of intercalative compounds will yield superior drugs for chloroquine resistant malaria. The selective toxicity for plasmodia of such substances as a group will be subject to the same limitations as that of chloroquine or quinacrine. (2) Barring radically new developments, the most promising approach to treating chloroquine resistant falciparum malaria will be the administration of synergistic mixtures of existing drugs which potentiate each other's antiplasmodial actions at pharmacologically tolerated levels of the individual substances. (Author)

Descriptors :   (*ANTIMALARIALS, RESISTANCE(BIOLOGY)), MOLECULAR PROPERTIES, DEOXYRIBONUCLEIC ACIDS, RIBONUCLEIC ACIDS, BIOSYNTHESIS, INHIBITION, CINCHONA ALKALOIDS, GERMICIDES, RIBOSOMES, ANTIMETABOLITES, TOXICITY, CHROMATOGRAPHIC ANALYSIS, ENZYMES, MOLECULAR ASSOCIATION, PLASMODIUM, DISEASES, TOXIC TOLERANCES.

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE