Accession Number : AD0837153

Title :   THYROIDAL DYSFUNCTION DURING SIMULATED ALTITUDE CONDITIONS,

Corporate Author : ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA

Personal Author(s) : Mulvey, Philip F., Jr

Report Date : 1968

Pagination or Media Count : 10

Abstract : Previous studies have indicated various degrees of thyroidal dysfunction in rats during exposure to high altitudes usually by simulated techniques. This study was undertaken to determine whether acute exposure to hypoxic conditions of simulated 15,000 ft. (429 mm Hg), exerts its effect on the trapping of 131 iodine and/or the processes of organification in the biosynthesis of thyroxine and its release from the thyroid gland of the rat. The data obtained in the present study indicated that the conversion of radiomonoiodotyrosine (MIT-131I) to radiodiiodotyrosine (DIT-131I) and the synthesis of radiothyroxine (T4-131I) were significantly inhibited by hypoxia. In addition, total plasma radioactivity (131I) and newly formed protein bound iodine (PB131I) from hypoxic rats were significantly lower compared with control animals. (Author)

Descriptors :   *THYROID GLAND), (*HYPOXIA, HIGH ALTITUDE, STRESS(PHYSIOLOGY), THYROXINE, BIOSYNTHESIS, SECRETION, RADIOACTIVE ISOTOPES.

Subject Categories : Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE