Accession Number : AD0837485

Title :   STIMULONS, THE ANTAGONISTIC FACTORS OF THE INTERFERON WHICH PROMOTE THE INTRACELLULAR MULTIPLICATION OF VIRUSES,

Corporate Author : ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s) : Chany, Charles ; Brailovsky, Carlos

Report Date : 07 NOV 1966

Pagination or Media Count : 6

Abstract : The findings lead to the assumption that the viruses induce -- in the cells -- the formation of substances which promote their multiplication, at the expense of the cell defense factor. Some of them block the synthesis of the cellular RNA carriers and thus act upon the synthesis of all of the cell proteins, including the interferon. The stimulons on the other hand, do not act upon the synthesis of the interferon but do cancel out its action, even if they are administered 24 hours after the interferon. It appears very probable that such stimulons are induced in the cells by most of the viruses and that there is a balance between the stimulon and the interferon. The pathogenic or attenuated character of a virus could depend on the chronology of the appearance and interaction of these two antagonistic factors. Experiments now in progress seem to indicate that the stimulons are synthesized and act upon a rather early phase of the cycle of virus infection. (Author)

Descriptors :   (*VIRUSES, REPRODUCTION(PHYSIOLOGY)), RIBONUCLEIC ACIDS, INHIBITION, BIOSYNTHESIS, PROTEINS, ATTENUATION, GENETICS, FRANCE.

Subject Categories : Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE