Accession Number : AD0849672

Title :   Skin Sensitization Potential of the Riot Control Agents CA, DM, CN, and CS in Guinea Pigs.

Descriptive Note : Technical rept. Jul 66-Oct 67,

Corporate Author : EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

Personal Author(s) : Rothberg, Sidney

Report Date : MAR 1969

Pagination or Media Count : 23

Abstract : It has been reported that o-chlorobenzylidene malononitrile (CS) showed evidence of a skin-sensitizing potential in man. This prompted a basic study of the skin sensitization capacity of CS and three other riot control agents in guinea pigs. The agents were administered by the intradermal or topical routes, or both, over a period of several weeks. Following an incubation period, the animals were challenged with suberythemal doses and readings were taken after a 72-hr observation period. It was concluded that: (1) neither CA nor DM produces skin sensitization in guinea pigs when administered intradermally; and (2) both CN and CS produce skin sensitization in guinea pigs when administered intradermally or topically. (Author)

Descriptors :   (*NONLETHAL AGENTS, SKIN(ANATOMY)), (*SKIN(ANATOMY), ANTIGEN ANTIBODY REACTIONS), IRRITATING AGENTS, TEAR GAS, CS AGENTS, VOMITING AGENTS, HAZARDS, ANAPHYLAXIS, IMMUNITY, GUINEA PIGS, INJECTIONS(MEDICINE), EXPOSURE(PHYSIOLOGY), DOSAGE, CHEMICAL WARFARE AGENTS, TROPICAL REGIONS, WOUNDS AND INJURIES.

Subject Categories : Anatomy and Physiology
      Chemical, Biological and Radiological Warfare

Distribution Statement : APPROVED FOR PUBLIC RELEASE