Accession Number : AD0857130

Title :   The Effect of Altitude Acclimatization Upon the Susceptibility of Mammals to Oxygen Poisoning.

Descriptive Note : Annual rept. no. 1 (Final), 1 Dec 68-28 Feb 69.

Corporate Author : WRIGHTSVILLE MARINE BIO-MEDICAL LAB WILMINGTON NC

Report Date : 27 JUN 1969

Pagination or Media Count : 4

Abstract : Vascular changes are recognized as the earliest evidence of pulmonary damage at elevated oxygen tensions. These changes are associated with an increase in alveolar capillary surface area and with evidence of circulatory congestion in the pulmonary bed. This development appears to be related to an increased resistance in the pulmonary veins and venules the cause of which is not yet clear. Altitude acclimatization has been reported to be uniformly associated with an increased number of alveolar and adventitial capillaries. Congestion and pulmonary edema are prominent parts of the acute high altitude syndrome, especially as observed in previously well acclimatized subjects. The lung of the altitude acclimatized subject have been placed under the necessity of becoming adapted to functioning under the very circulatory conditions which form a prominent part of the pathology of hyperoxia. Such tissue might plausibly be expected to be capable of coping more effectively with the pathophysiological effects of pulmonary hyperoxia than unconditioned lungs of non-acclimatized animals.

Descriptors :   *POISONING, *OXYGEN, *HYPOXIA, ACCLIMATIZATION, TOXICITY, LUNG, MAMMALS, RESPIRATORY DISEASES, EDEMA, RATS, BLOOD CIRCULATION, HIGH ALTITUDE.

Subject Categories : Stress Physiology
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE