Accession Number : AD0860413

Title :   Controlled Oxidation-Reduction Potential in Submerged Tissue Culture Fermentation in Pilot-Scale Fermentors,

Corporate Author : FORT DETRICK FREDERICK MD

Personal Author(s) : Wiles, Carlton C. ; Smith, Vernon C.

Report Date : SEP 1969

Pagination or Media Count : 32

Abstract : Operations of a submerged tissue culture pilot facility are presented. Oxidation-reduction potential (ORP) was controlled, and its effects on fermentation are discussed. A strain of Earle's L cells was grown to as high as 4400000 viable cells per ml. Cultures were grown without the aid of antibiotics. An internal standard was developed to calibrate the redox measuring system. (Author)

Descriptors :   (*TISSUE CULTURE CELLS, OXIDATION REDUCTION REACTIONS), (*FERMENTATION, PILOT PLANTS), OXIDATION, TISSUE CULTURE, ANTIBIOTICS, GROWTH(PHYSIOLOGY), MEASUREMENT, CELLS(BIOLOGY).

Subject Categories : Microbiology
      Industrial Chemistry and Chemical Processing

Distribution Statement : APPROVED FOR PUBLIC RELEASE