Accession Number : AD0865136

Title :   The Cutaneous Irritant Reaction to Agent o-Chlorobenzylidene Malononitrile (CS). I. Quantitation and Racial Influence in Human Subjects.

Descriptive Note : Technical rept. Sep 68-Apr 69,

Corporate Author : EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

Personal Author(s) : Weigand, Dennis A. ; Mershon, Millard M.

Report Date : FEB 1970

Pagination or Media Count : 21

Abstract : The purpose of this study was to determine whether a significant difference exists between Negroes and Caucasians in cutaneous irritant reaction to CS, and to try to localize to a specific layer of skin any relative protective principle which Negro skin might have. A determination as to whether racial difference exists in the symptomatic response of the skin was also sought. Standardized exposures were given on the volar surface of the forearm and the back by an occlusive patch-test technique, utilizing duration of exposure as the variable. A range of exposures, low to high, was given each subject, and the minimal perceptible erythema (MPE) was read. The impression that Negroes are less susceptible to irritant determatitis from CS2 was confirmed. On both forearm and back, the production of MPE required approximately twice the exposure time on Negroes as on Caucasians. The racial difference in reactivity is lost if stratum corneum (the barrier layer) is removed. Neither is there a racial difference in the stinging sensation, which is caused by CS that penetrates by the transappendageal route. It is proposed that the difference in the melanin content of the stratum corneum between the two races may account for the difference in reactivity; i.e., that melanin exerts a protective influence, possibly by reacting with CS. (Author)

Descriptors :   (*CS AGENTS, TOLERANCES(PHYSIOLOGY)), (*SKIN(ANATOMY), CS AGENTS), (*ORGANIC PIGMENTS, CS AGENTS), RESPONSE(BIOLOGY), IRRITATING AGENTS.

Subject Categories : Anatomy and Physiology
      Chemical, Biological and Radiological Warfare

Distribution Statement : APPROVED FOR PUBLIC RELEASE