Accession Number : AD0881921

Title :   Prevention of Plaque and Gingival Disease by Victamine C and Its Derivatives Incorporated in Pills, Chewing Gum and Mouthwash.

Descriptive Note : Progress rept. no. 10 (Final), 1 Mar 69-30 Sep 70,

Corporate Author : TUFTS UNIV BOSTON MA SCHOOL OF DENTAL MEDICINE

Personal Author(s) : Turesky, Samuel S.

Report Date : FEB 1971

Pagination or Media Count : 19

Abstract : An in vitro procedure was developed to screen surface-active chemicals, which because of their adhesive and antibacterial properties, might be potential inhibitors of plaque formation. Teeth were pretreated chemically, immersed in water for at least five minutes, and then incubated in trypticase-sucrose broth inoculated with a pure isolate of 'plaque' forming streptococcus mutans. Absence of bacterial growth on the specimen or in the test tube denoted plaque inhibition. The in vitro findings (1) confirm the efficacy of certain chemicals reported to inhibit plaque formation in vivo; (2) point to the importance of a cationic molecular configuration about a nitrogen atom in these chemicals; (3) suggest that inhibition is provided by adsorption to the tooth surface followed by slow release, and (4) suggest that there may be an optimum aqueous lipid partition coefficient for maximal plaque inhibition by surface-active chemicals. (Author)

Descriptors :   *AMINES), (*DENTISTRY, MOUTH, TEETH, DISEASES, CONTROL, MICROBIOLOGY, SURFACE ACTIVE SUBSTANCES, CHEMICALS, GUANIDINES, AMMONIUM COMPOUNDS, ORGANIC PHOSPHORUS COMPOUNDS.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE