Accession Number : AD0923709

Title :   Prevention of Influenza and Other Respiratory Diseases.

Descriptive Note : Annual progress rept. 1 Jun 73-31 May 74,

Corporate Author : COLORADO UNIV AT DENVER MEDICAL CENTER

Personal Author(s) : Meiklejohn, Gordon ; Eickhoff, Theodore C.

Report Date : AUG 1974

Pagination or Media Count : 35

Abstract : Tests fro H.I. antibody response to test lots of B/HK/72 in September, 1973, containing 250, 500, or 1000 CCA units showed good seroconversion rates and elevation of titers when late (e 22) egg passage virus was used. A second injection of vaccine evoked little further increase. Vaccine of standard military formula, containing A2/Eng/72 and B/Mass/71 evoked a highly satisfatory response to A2/Eng/72 and to the more recent A/Port Chalmers/73 and a moderate response to B/HK/72. Significant systemic or local reactions were not observed following vaccination, even when the standard bivalent 1000 CA unit vaccine and the 500 CCA unit B/HK/72 vaccine were given simultaneously. A volunteer field trial designed to compare the incidence of influenza A or B in men receiving bivalent vaccine containing A2/Eng/42 and B/Mass/71 with that in men who received only B/HK/72 vaccine was set up. A small outbreak of influenza B, caused by strains closely related to B/HK/72 occurred in February and March, 1974. A small outbreak of influenza A caused by strains closely related to A/Eng/72 and A/Port Chalmers/73 occurred in late March and April, 1974. The number of cases in both cases were small in the study group and, while there was a suggestion of a protective effect, the differences between those who had received influenza A vaccine and those who had not was not significant. No cases of adenovirus illness due to Types 4 or 7 were found among 400 men with febrile U.R.I.

Descriptors :   (*INFLUENZA VIRUS, RESPIRATORY DISEASES), (*VACCINES, INFLUENZA VIRUS), INFECTIOUS DISEASES, VIRUS DISEASES, ANTIGEN ANTIBODY REACTIONS, IMMUNIZATION, ADENOVIRUSES, DOSAGE, AIR FORCE PERSONNEL, FIELD TESTS.

Subject Categories : Medicine and Medical Research
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE