Accession Number : ADA015510

Title :   Synthesis of Substituted Piperazines and Related Compounds as Antimalarials.

Descriptive Note : Annual rept. 1 Jun 72-31 May 73,

Corporate Author : ABBOTT LABS NORTH CHICAGO ILL

Personal Author(s) : Geiszler,A. O.

Report Date : 15 JAN 1975

Pagination or Media Count : 45

Abstract : The report presents research on the preparation oof 1-(p-methoxycinnamoyl)-4-(5-phenyl-4-oxo-2-oxazolin-2-yl) piperazine. Seventy-one compounds were prepared. The compounds which showed antimalarial activity against P. berghei in mice or P. gallinaceum in chicks are listed. The methods used to prepare the compounds are described. The most active compound, 1,4-methoxy-cinnamoyl-4-(5-p-chlorophenyl-4-oxo-2-oxazolin-2-yl)piperazine, RMS-17 (BB 45785) is as active as the lead compound RM-682 (AX 88991).

Descriptors :   *Antimalarials, *Chemotherapeutic agents, Synthesis(Chemistry), Nitrogen heterocyclic compounds, Oxygen heteracyclic compounds, Drugs, Malaria, Parasitic diseases

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE