Accession Number : ADA017131

Title :   Inhibition of Cyclic Adenosine 3',5'-Monophosphate-Dependent Protein Kinase by Chlorpromazine.

Descriptive Note : Technical rept. Jun 74-Feb 75,

Corporate Author : EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

Personal Author(s) : Maxwell,Donald M.

Report Date : OCT 1975

Pagination or Media Count : 10

Abstract : Chlorpromazine (CPZ) protects rabbits against anticholinesterase poisoning, while cyclic adenosine 3',5'-monophosphate (cAMP) potentiates the toxicity of anticholinesterase compounds. Chlorpromazine is shown to be a noncompetitive inhibitor of cAMP activation of cAMP-dependent protein kinase (PK). The metabolic and pharmacological consequences of CPZ inhibition of PK and its possible relationship to protection against anticholinesterase agents are discussed.

Descriptors :   *CHLORPROMAZINE, *CHOLINESTERASE INHIBITORS, ENZYMES, METABOLISM, PHARMACOLOGY, PHENOTHIAZINES, THERAPY, PROPHYLAXIS, LETHAL AGENTS, CHEMICAL AGENTS, INHIBITION, RABBITS, LABORATORY ANIMALS, EXPERIMENTAL DATA, TOXICOLOGY, POISONING

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE