Accession Number : ADA017473

Title :   Hazard Evaluation of Candidate Face Net Repellent AI3-5974, 1-Butyryl-1,2,3,4-tetrahydroquinoline.

Descriptive Note : Special study Dec 73-Jul 75,


Personal Author(s) : Angerhofer,Richard A. ; Weeks,Maurice H. ; Pope,Conrad R.

Report Date : 14 NOV 1975

Pagination or Media Count : 26

Abstract : A hazard evaluation of the candidate face net repellent 1-butyryl-1,2,3,4-tetrahydroquinoline (AI3-5974) was performed by means of laboratory animal studies using rats, rabbits and guinea pigs. The technical grade compound did not produce primary irritation when applied to the intact or abraded skin of rabbits. There were no harmful effects resulting from a single application to the eyes of rabbits. AI3-5974 did not produce skin sensitization in guinea pigs. Data indicated a moderate toxic hazard from accidental ingestion. A slight photochemical skin irritation reaction was observed in rabbits. An 8-hour inhalation exposure of rats to a saturated vapor of AI3-5974 generated at 24C resulted experimentally in no deleterious effects. Repeated exposures under conditions similar to those mentioned above resulted in interstitial pneumonitis. It is recommended that AI3-5974 not be approved for testing as a candidate face net repellent.

Descriptors :   *Insect repellents, *Toxicity, *Irritant compounds, Skin(Anatomy), Eye, Bioassay, Laboratory animals, Ingestion(Physiology), Inhalation, Exposure(Physiology), Toxicology, Humans

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE