Accession Number : ADA017474

Title :   Hazard Evaluation of Candidate Face Net Repellent AI3-22851, 2-Chloroethyl m-Methylcarbanilate.

Descriptive Note : Special study Dec 73-Jul 75,


Personal Author(s) : Angerhofer,Richard A. ; Weeks,Maurice H. ; Pope,Conrad R.

Report Date : 14 NOV 1975

Pagination or Media Count : 26

Abstract : A hazard evaluation of the candidate face net repellent 2-chloroethyl m-methyl=carbanilate (AI3-22851) was performed by means of laboratory animal studies using rats, rabbits and guinea pigs. The technical grade compound did not produce primary irritation when applied to the intact or abraded skin of rabbits. No corneal injury, iritis or conjunctivitis was observed after a single application of the technical grade compound to the eyes of rabbits. AI3-22851 did not produce a skin sensitization reaction in guinea pigs or photochemical irritation in rabbits. Data indicated a moderate toxic hazard from accidential ingestion. Acute aerosol as well as acute and subchronic saturated vapor inhalation exposures of rats resulted experimentally in no deleterious effect. It is recommended that AI3-22851 be approved for testing as a candidate face net repellent. While this compound is in the research and development stage, personnel potentially exposed to this chemical should be under medical surveillance until such time as more definitive toxicologic data are available.

Descriptors :   *Insect repellents, *Toxicity, *Irritant compounds, Toxicology, Bioassay, Laboratory animals, Eye, Skin(Anatomy), Inhalation, Ingestion(Physiology), Humans

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE