Accession Number : ADA017516

Title :   Preliminary Hazard Evaluation of Candidate Insect Repellent AI3-70646-bGa.

Descriptive Note : Special study Apr-Jun 75,


Personal Author(s) : Metker,Leroy W. ; Lovre,Stanton C. , Jr

Report Date : 20 NOV 1975

Pagination or Media Count : 10

Abstract : A hazard evaluation of the candidate insect repellent AI3-70646-bGa performed by means of laboratory animal studies using New Zealand White rabbits, Sprague-Dawley/Wistar derived rats, and Hartley guinea pigs. Mild corneal opacity, iritis, and conjunctivitis were observed after a single application of the technical grade compound to the eyes of rabbits. No primary skin irritation was noted after a single application of the technical grade compound to the intact and abraded skin of rabbits. No toxic photoirritation reactions were seen with this compound. A mild sensitization reaction was elicited with intradermal injections of a 0.1 percent solution in five out of 20 guinea pigs. Data indicate moderate acute toxic hazard from accidental ingestion of this material. Based on these findings, it is recommended that USDA Proprietary Compound No. AI3-70646-bGa, not be approved for testing.

Descriptors :   *Insect repellents, *Toxicity, *Irritant compounds, Bioassay, Laboratory animals, Rabbits, Rats, Guinea pigs, Eye, Skin(Anatomy), Ingestion(Physiology)

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE