Accession Number : ADA017518

Title :   Dermal Penetration of Radio-Labeled Topical Repellents Cyclohexamethylene Carbamide and n-Butylsulfonimido cyclohexamethylene.

Descriptive Note : Special study Aug 74-Feb 75,

Corporate Author : ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD

Personal Author(s) : Snodgrass,Hubert L. , Jr. ; Weeks,Maurice H.

Report Date : 19 NOV 1975

Pagination or Media Count : 10

Abstract : The percutaneous absorption of radio-labeled topical insect repellents cyclohexamethylene carbamide and n-butylsulfonimidocyclohexamethyelen was determined following application to the intact skin of rabbits. Urine excretion of cyclohexamethylene carbamide was 64.9 percent of applied dose after seven days. n-Butylsulfonimidocyclohexamethylene excreted in the urine was 48.4 percent of applied dose after seven days. Only trace quantities of labeled repellents were found in tissue specimens of rabbits monitored seven days after topical application.

Descriptors :   *Insect repellents, *Skin(Anatomy), *Absorption(Biological), Humans, Rabbits, Laboratory animals, Penetration, Tissues(Biology), Labeled substances, Experimental data, Toxicology, Sulfur heterocyclic compounds, Sulfones, Nitrogen heterocyclic compounds

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE