Accession Number : ADA017958

Title :   The Comparative Toxicity of Heated and Unheated 1%CR in Propylene Glycol/Water (80/20).

Descriptive Note : Technical rept. Oct 74-Feb 75,

Corporate Author : EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

Personal Author(s) : Biskup,Ronald K. ; Malloy,John C. ; Manthei,James H. ; Wiles,Joseph S.

Report Date : NOV 1975

Pagination or Media Count : 13

Abstract : The contents of riot control devices that are carried in vehicles in summer weather can reach temperatures as high as 150F. The purpose of this study was to determine if the irritancy of 1%CR in propylene glycol/water increases when the solution is warm. Rabbits were dosed acutely by the intratracheal, ocular, and cutaneous routes and chronically by the ocular and cutaneous routes with heated and unheated 1%CR in propylene glycol/water and propylene glycol/water alone, and the effects were noted. There were no differences in local toxicological effects of unheated and heated 1%CR in propylene glycol/water (80/20) and no signs of systemic toxicity in any of the animals. The data indicate no increases in the irritant properties of the heated solution.

Descriptors :   *RIOT CONTROL AGENTS, HEATING, IRRITANT COMPOUNDS, TOXICITY, NITROGEN HETEROCYCLIC COMPOUNDS, OXYGEN HETEROCYCLIC COMPOUNDS, HAZARDS, BIOASSAY, RABBITS, LABORATORY ANIMALS, SKIN(ANATOMY), EYE, TRACHEA

Subject Categories : Toxicology
      Chemical, Biological and Radiological Warfare

Distribution Statement : APPROVED FOR PUBLIC RELEASE