Accession Number : ADA018259

Title :   Data on the Mechanism of the Fibrogenic Action of Asbestos Dust,


Personal Author(s) : Kogan,F. M. ; Troitskii,S. Yu. ; Udilova,N. N.

Report Date : 30 JUL 1975

Pagination or Media Count : 12

Abstract : The short-fibered chrysotile-asbestos of serpentine and the serpentine show a fibrogenic action on the lung tissue, however, it is more pronounced in the asbestos. The opinion of some authors on the biological inertness of the serpentine and the short fibers of asbestos was not verified. Data indicate that the formation of fibrosis was connected not with the solution of silicic acid nor with the fibroacerous shape of the asbestos particles. The authors hypothesize that asbestos and serpentine, despite the significant morphological differences between them, are capable of causing fibrosis since the asbestos, which possesses a tubular structure, also has a large specific surface. The probability of the formation of active chemosorptive centers in it are higher than in the serpentine. In conclusion, it is possible to show that in the fibrogenic action of asbestos; the decisive properties are the physical-chemical and colloidal properties of its surface.

Descriptors :   *Asbestos, *Toxicology, Respiratory system, Dust, Lung, Silicon dioxide, Physicochemical properties, Pathology, Histology, Laboratory animals, Experimental data, USSR, Translations

Subject Categories : Toxicology
      Environmental Health and Safety

Distribution Statement : APPROVED FOR PUBLIC RELEASE