Accession Number : ADA018564

Title :   Direct Determination of the Optical Purities of Phosphorus Compounds Using Nuclear Magnetic Resonance Spectroscopy.

Descriptive Note : Technical rept. Jul 74-May 75,

Corporate Author : EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

Personal Author(s) : Szafraniec,Linda L.

Report Date : NOV 1975

Pagination or Media Count : 26

Abstract : Tris(3-trifluoroacetyl-d-camphorato)europium (III), Eu(facam)3, is a useful NMR shift reagent for the direct determination of the optical purities of many phosphorus compounds of interest to these laboratories. In the presence of the optically active lanthanide chelate, the optical isomers (enantiomers) have nonequivalent NMR spectra. Generally, the shift differences are large enough for complete separation of at least one set of enantiotopic signals, and enantiomeric compositions (optical purities) can be determined directly from relative peak areas. While Eu(facam)3 interacts successfully with most phosphoryl compounds of interest, it does not interact well with thiophosphoryl or trivalent phosphorus compounds. Thus, it cannot be used to determine the enantiomeric compositions of these classes of compounds.

Descriptors :   *Nuclear magnetic resonance, *Organic phosphorus compounds, Shifting, Rare earth compounds, Purity, Chelate compounds, Europium compounds, Molecular isomerism

Subject Categories : Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE