Accession Number : ADA018677

Title :   Syphilis Vaccine and Immune Mechanisms.

Descriptive Note : Annual rept. no. 4, 1 Jan-31 Dec 75,

Corporate Author : CALIFORNIA UNIV LOS ANGELES DEPT OF MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Personal Author(s) : Miller,James N.

Report Date : 31 DEC 1975

Pagination or Media Count : 62

Abstract : Development of an Effective and Practical Vaccine Against Experimental and Human Syphilis. No immunity to the intradermal challenge of 500 T. pallidum was demonstrated among rabbits vaccinated intramuscularly at 4-week intervals with a total of 4 vaccine doses, each containing an equal volume of approx. 4 x 10 to the 9th power gamma irradiated (1,000,000 rads), liquid-nitrogen preserved T. pallidum and an alginate-gluconate adjuvant; each of the vaccinated animals developed VDRL and FTA-ABS antibodies, while none developed TPI antibody nor exhibited an anamnestic response following challenge. The possibility that irradiation with 1,000,000 rads damages the immunogens responsible for stimulating host-resistance, has led to the design of experiments in which T. pallidum gamma-irradiated with 650,000 rads will be utilized in the protocol described above in an effort to achieve a clearly demonstrable complete immunity. (Author)

Descriptors :   *Treponema pallidum, *Vaccines, *Syphilis, Rabbits, Diseases, Cultures(Biology), Mobility, Complement(Biology), Neutralization, Resistance, Immunity, Irradiation, Response(Biology), Antibodies, Immune serums, Incubation, Lymphocytes, Immunosuppression, Purification

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE