Accession Number : ADA018894

Title :   The Effect of Hyberbaric Oxygen and Helium on Virus Replication and Host Pathology.

Descriptive Note : Final rept. 1 Apr 68-31 Jul 74,

Corporate Author : SETON HALL UNIV SOUTH ORANGE N J DEPT OF BIOLOGY

Personal Author(s) : Orsi,Ernest V.

Report Date : 31 DEC 1975

Pagination or Media Count : 8

Abstract : There is strong experimental evidence that virus infection after exposure to hyperbaric oxygen stress 'favors the virus over the host cell'. Viral mRNA degredation is lessened by diminution of lysosomal RNA-ase leakage. In turn the interferon synthesising capability of the host is markedly reduced by direct action of hyperbaric oxygen or compounds such as adrenochrome which mimic its action under normal pressure.

Descriptors :   *Viruses, *Helium, Hyperbaric conditions, Stress(Physiology), Oxygen, Ribonucleic acids, Exposure(Physiology), Microorganisms, Microbiology, Pathogenic microorganisms, Reproduction(Physiology), Biosynthesis, Hosts(Biology), Pathology, Virus diseases, Adrenal glands, Experimental data, Cultures(Biology)

Subject Categories : Stress Physiology
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE