Accession Number : ADA018992

Title :   Measurement of Antifolate Drugs by Microbiological Assay.

Descriptive Note : Annual rept. no. 2, 1 Jul 74-30 Jun 75,

Corporate Author : CINCINNATI UNIV OHIO DEPT OF ENVIRONMENTAL HEALTH

Personal Author(s) : Smith,Carl C. ; Genther,Clara S.

Report Date : 15 DEC 1975

Pagination or Media Count : 71

Abstract : ;Contents: Interim report no. 10 -- Measurement of antifolate drug levels by microbiological assay. Plasma levels of 4,6-diamino-1-(2,4,5-trichloro-phenoxypropyloxy)- 1,2-dihydro-2,2-dimethyl-s-triazine WR-99,210; Interim report no. 11 -- Measurement of antifolate drugs by microbiological assay. Plasma levels of 2,4-diamino-6-(2-naphthyl)-sulfonylquinazoline (WR-158,122) in 11 human subjects given combinations of WR-158,122 and sulfadiazine. Interim report no. 12 -- Measurement of antifolate drugs by microbiological assay. Plasma levels of 1-(2-4,5-trichlorophenoxy-propyloxy)-1,2-dihydro-2,2-dimethyl-s-triazine (WR-99,210) in 8 human subjects given single oral doses of 50 or 250 mg.

Descriptors :   *Drugs, Folic acid, Bioassay, Streptococcus, Bacteria, Microbiology, Assaying, Measurement, Stability, Tables(Data), Humans, Pharmacology, Dosage, Triazines, Nitrogen heterocyclic compounds

Subject Categories : Microbiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE