Accession Number : ADA019007

Title :   Humoral Immunity in Experimental Syphilis. I. The Demonstration of Resistance Conferred by Passive Immunization. II. The Relationship of Neutralizing Factors in Immune Serum to Acquired Resistance,

Corporate Author : CALIFORNIA UNIV LOS ANGELES DEPT OF MICROBIOLOGY AND IMMUNOLOGY

Personal Author(s) : Bishop,Nancy H. ; Miller,James N.

Report Date : 02 DEC 1975

Pagination or Media Count : 67

Abstract : Evidence of a role for humoral factor(s) in immunity to experimental syphilis has been provided by the demonstration that passive immunization of rabbits by daily intravenous injections of immune serum significantly delays the appearance and markedly diminishes the severity and duration of lesions which develop following challenge with Treponema pallidum. Five rabbits were injected daily over 37 days with 3 ml/kg body weight of pooled immune rabbit serum and challenged intradermally 4 hours after the initial serum injection with 1,100 T. pallidum, Nichols strain, at each of 4 sites. The animals developed atypical lesions of short duration after an average delay in onset of 28 days beyond the development of typical lesions in control animals. The failure of passive immunization to provide complete protection was evident not only in the development of the atypical lesions, but also in the demonstration of disseminated infection in the tissues of 3 of the 4 surviving animals 7 months after challenge.

Descriptors :   *Syphilis, *Immunity, *Venereal diseases, Treponema pallidum, Immunization, Bacterial diseases, Infectious diseases, Immune serums, Rabbits, Laboratory animals, Experimental data, Injections(Medicine)

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE