Accession Number : ADA019031

Title :   Chemotherapy Studies on Schistosomiasis.

Descriptive Note : Annual technical rept. (Final) 1 Apr 74-30 Jun 75,

Corporate Author : BRASILIA UNIV (BRAZIL)

Personal Author(s) : Prata,Aluizio Rosa ; Radke,Myron G.

Report Date : 31 JUL 1975

Pagination or Media Count : 9

Abstract : The University of Brasilia and USAMRU (WRAIR) Brasilia began in October 1974 to test selected compounds for prophylactic activity against schistosomiasis mansoni in mice. Using the mortality test system to identify active drugs, a total of 655 drugs were tested and final results are available for 482 drugs (173 are in various stages of testing). The prophylactic anti-schistosomal drug test results for these 482 WRAIR bottle number drugs were: (1) 402 negative, (2) 68 toxic, and (3) 12 active (9 different drugs). The discreet nature of these active compounds submitted for testing does not permit disclosure. (Author)

Descriptors :   *Schistosoma mansoni, *Chemotherapy, *Prophylaxis, Preventive medicine, Mice, Drugs, Brazil, Laboratory tests, Snails, Cercariae, Tropical medicine, Selection, Parasitology, Schistosomiasis, Chemotherapeutic agents, Medical research

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE