Accession Number : ADA019268

Title :   Effects of Eserine upon Light Sensitivity and Dark Adaptation.

Descriptive Note : Special publication Jan 72-Dec 73,

Corporate Author : EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

Personal Author(s) : Trussov,M. S.

Report Date : NOV 1975

Pagination or Media Count : 13

Abstract : The author, a medical science degree candidate from the eye clinic, Khabarovsk Medical Institute, studied the effects of systemic administration of eserine upon light sensitivity and dark adaptation on 94 subjects. After injection (probably intramuscular) of eserine, the light sensitivity increased noticeably and the dark adaptation process accelerated. He explained these results in terms of the accumulation of acetylcholine in all neural synapses in the visual system: viz., retina, lateral geniculate body, and visual cortex. He emphasized that the process of visual adaptation cannot be reduced only to synthesis of rhodopsin. The maximum increase of light sensitivity, measured with a Kravkov-Vishnevsky apparatus, occurred 1.5 to 2.0 hours after injection of eserine and lasted for 6 to 12 hours. Light sensitivity accelerated the dark adaptation time as measured with the A.M. Belostotsky-Gofman adaptometer. To achieve these effects, a relatively small dose range (0.5 to 0.8 ml of a 0.1% water solution of eserine) must be used. A dosage of 0.3 ml of 0.1% solution was not sufficient to achieve the desired effect, and 1.0 ml of 0.1% solution caused undersired effects: vertigo, increased heart 'beat,' and nausea. A dosage of 0.3 ml of 0.1% solution was not sufficient to achieve the desired effect, and 1.0 ml of 0.1% solution caused undersired effects: vertigo, increased heart 'beat,' and nausea.

Descriptors :   *Dark adaptation, *Light, *Sensitivity, Cholinesterase inhibitors, Humans, Acetylcholine, Eye, Synapsis, Nerve transmission, Injections(Medicine), Translations, USSR

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE