Accession Number : ADA020089

Title :   Changes of delta-Aminolevulinic Acid Synthetase Activity in Erythroid by Various Drugs and Infectious States.

Descriptive Note : Annual rept. Jun 73-Jun 74,

Corporate Author : JICHI MEDICAL SCHOOL MINAMIKOCHI-MACHI (JAPAN)*

Personal Author(s) : Takaku,Fumimaro

Report Date : JUN 1975

Pagination or Media Count : 14

Abstract : To clarify the biochemical mechanism of chloramphenicol induced erythroid suppression, effect on ALA (delta-aminolevulinic acid) synthetase activity in erythroid cells was studied. Chloramphenicol mice had no effect on ALA synthetase activity. However, ALA synthetase activity in erythroblasts was decreased in some patients treated with thiamphenicol an analogue of chloramphenicol. It is speculated that thiamphenicol may have induced a proliferation of a clone of erythroblasts with low ALA synthetase activity.

Descriptors :   *Anemias, *Erythrocytes, Enzyme inhibitors, Nitrogen compounds, Enzymes, Biochemistry, Laboratory animals, Mice, Experimental data, Blood diseases, Blood cells, Pathogenesis, Bone marrow, Chlorine compounds, Amino acids

Subject Categories : Biochemistry
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE