Accession Number : ADA070736

Title :   The Efficacy of Therapy at Doses Suggested for Self-Aid against GD Poisoning.

Descriptive Note : Technical paper,

Corporate Author : DEFENCE RESEARCH ESTABLISHMENT SUFFIELD RALSTON (ALBERTA)

Personal Author(s) : Lipp,J. A.

Report Date : APR 1979

Pagination or Media Count : 14

Abstract : Monkeys were exposed to 1 LD50 of GD and treated with a combination of clonazepam, atropine and toxogonin at doses suggested for self-aid. The doses used were based on equivalent human doses of 2 mg/man of atropine, 5 mg/man of clonazepam and 280 mg/man of toxogonin. This therapy, given by intramuscular injection when the initial signs of poisoning occurred, adequately suppressed the abnormal EEG and muscular activity. Atropine reversed cardiac arrhythymia, but the GD-induced respiratory depression and bradycardia appeared more resistant and in some animals additional atropien was necessary. Control animals that only received therapy did not appear to be incapacitated. The results of this study suggest that this therapy would produce a degree of protection against GD poisoning and could be used as self-aid. (Author)

Descriptors :   *ANTICONVULSANTS, PHYSIOLOGICAL EFFECTS, POISONING, GD AGENT, ATROPINE, CONVULSIVE DISORDERS, DRUG TOLERANCE, SELF TREATMENT.

Subject Categories : TOXICOLOGY
      MICROBIOLOGY

Distribution Statement : APPROVED FOR PUBLIC RELEASE

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