Accession Number : ADA111885

Title :   Mutagenicity Evaluation of Picramic Acid in the Ames Solmonella/Microsome Plate Test.

Descriptive Note : Segment rept.,


Personal Author(s) : Jagannath,D R

PDF Url : ADA111885

Report Date : Feb 1979

Pagination or Media Count : 70

Abstract : The test compound was examined for mutagenic activity in a series of in vitro microbial assays employing Salmonella and Saccharomyces indicator organisms. The compound was tested directly and in the presence of liver microsomal enzyme preparations from Aroclor-induced rats. The compound was tested over a series of concentrations such that there was either quantitative or qualitative evidence of some chemically-induced physiological effects at the high dose level. The low dose in all cases was below a concentration that demonstrated any toxic effect. The dose range employed for the evaluation of this compound was from 0.5 micrograms to 1000 micrograms per plate. (Author)

Descriptors :   *Microsomes, *Microbiological tests, Mutagens, Salmonella, Indicators, In vitro analysis, Bioassay

Subject Categories : Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE