Accession Number : ADA112358

Title :   Chemical Carcinogen-Induced Changes in tRNA Metabolism in Human Cells.

Descriptive Note : Interim rept. 1 Oct 80-30 Sep 81,

Corporate Author : OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS

Personal Author(s) : Trewyn,Ronald W

PDF Url : ADA112358

Report Date : Nov 1981

Pagination or Media Count : 6

Abstract : Changes in nucleic acid catabolism were found in human cells transformed by an activated derivative of 1,2-dimethylhydrazine, with increased generation of 7-methylguanine being the major alteration. 7-Methylguanine was shown to inhibit the enzyme tRNA: guanine transglycosylase. This enzyme exchanges queuine (Q-base) for guanine in the first position of the anticodon of four different tRNA's, and tRNA's from transformed cells are Q-deficient. 7-Methylguanine was also found to induce Q-hypomodification of tRNA in normal cells. It is felt that the changes discovered in nucleic acid catabolism and modification may be involved in the expression of carcinogenesis. (Author)

Descriptors :   *Ribonucleic acids, *Carcinogens, Metabolism, Cells(Biology), Humans, Catabolism

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE