Accession Number : ADA112854

Title :   Hypertensive Effect of Brain Acetylcholinesterase Inhibition.

Descriptive Note : Final rept. 15 Nov 78-31 Dec 81,


Personal Author(s) : Brezenoff,Henry E

PDF Url : ADA112854

Report Date : 08 Mar 1982

Pagination or Media Count : 7

Abstract : Lethal or near-lethal doses of acetylcholinesterase (AChE) inhibitors cause respiratory depression and cardiovascular collapse. Lower doses, however, evoke a centrally-mediated increase in blood pressure. This hypertensive response occurs in a variety of animal species, including humans. The overall objective of this project was to study the central mechanisms involved in the pressor effect of AChE inhibitors and to determine the role of brain acetylcholine (ACh) in hypertensive states. To that end I believe the project was quite successful. We have defined the role of brain ACh in the central regulation of baroreceptor reflexes and have localized the site of this effect to the posterior hypothalamic nucleus. In addition, we have shown that in the spontaneously hypertensive rat, which appears to have enhanced central cholinergic activity, brain ACh is involved in maintaining the elevated blood pressure. As an offshoot of this project this last finding suggests new directions for antihypertensive therapy. (Author)

Descriptors :   *Acetylcholinesterase, *Enzyme inhibitors, Brain, Inhibition, Blood pressure, Physiological effects, Lethal dosage

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE