Accession Number : ADA112981

Title :   Narcotic Tolerance and Dependence Mechanism: A Neurological Correlate.

Descriptive Note : Annual progress rept. 1 Sep 74-31 Aug 75,

Corporate Author : CALIFORNIA UNIV SAN FRANCISCO SCHOOL OF MEDICINE

Personal Author(s) : Loh,Horace H

PDF Url : ADA112981

Report Date : Sep 1975

Pagination or Media Count : 46

Abstract : We have examined a number of factors which may be involved in both the acute and chronic actions of morphine and related narcotics. Special emphasis was placed on the role(s) of membrane lipids and proteins. The results clearly demonstrate that both acute and chronic morphine treatments have marked effects (both inhibitory and stimulatory) on brain protein and phospholipid turnover depending on the brain region examined. Unfortunately, the effects of morphine on protein and phospholipid synthesis do not seem in any reasonable way to be associated with the known localization of narcotic receptors. The possibility was tested that chronic morphine treatment may lead to miscoding in the formation of m-RNA and in this way produce a qualitative change in protein synthesis. Such changes were not observed. Chronic morphine treatment was, however, found to significantly increase brain chromatin template activity. Extensive investigations of the opiate receptor material were also performed.

Descriptors :   *Morphine, *Narcotics, Tolerances(Physiology), Proteins, *Biosynthesis, Phospholipids, Brain

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE